Zach Klein: Use Of Medical Cannabis In Israel – #CannaCosta2015

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Zach Klein: Use Of Medical Cannabis In Israel – #CannaCosta2015

well we start this part of the Tootsie with the presentation of the Israeli documentalist he did prescribe grass documentary showing the benefits of result cannabis he is currently finishing the scientists on the mythical dr. Raphael mechoulam so we hereby present cannabis being used in a nursing home I want to share with you my first encounter with cannabis as medicine and that was 15 years ago when my mom was diagnosed with breast cancer and had to go on chemotherapy and radiation Helen college east whispered in her ear that she should try to get Ashish or cannabis to alleviate the side effect of the treatment so she came back home and asked me about it what do we know about cannabis about ashish at that time the only thing I knew was from my experience in Dutch coffee shops little experience I must say so she had a really serious question what about the brain damage it was known back then that cannabis can cause brain damage that was the common knowledge and I really didn’t have any answer to that luckily at that ear professor Raphael mechoulam who is also known as the father of cannabinoids research appeared in the media as he warned Israel price the highest price for Science in Israel so it appeared in the media and then I went to listen to one of his lectures and it was a one-hour lecture a mind-blowing lecture actually because what he said was completely completely different from everything I knew and everyone around me knew about cannabis and its effect I went after the lecture to Professor sharam and asked him the question that my mother asked me will it cause brain damage to my mother so we looked at me and said well you didn’t listen to my lecture because in the lecture he actually explained that cannabinoids THC or endocannabinoids our protective neuroprotective so actually it’s the opposite from brain damage anyway I came back home with the new knowledge and information and my mother tried cannabis the story why I got cannabis at that time it’s not for now but she tried the cannabis and it helped her a lot I was amazed and it stayed with me for a long time I started researching and reading about it and then decided to make a documentary about it that was prescribed grass buffer so mature I’m started his research in 1964 with a bag of hashish that was smuggled from Lebanon and was caught in Israel by the police and the police gave professor McCollum the hashish for his research so he started walking on the hashish just 1964 gone in mechelen isolate the active ingredient in cannabis in which the THC and later mikhoonam continue to research the bio physiological mechanisms and how THC and other cannabinoids woke on our body to major cannabinoids we already heard about them CBD was isolated by a mature amo anch’io in 1963 and TC a year later by gone in surah today we know that there are more than 100 different cannabinoids and this clip tells about research that was done 34 years ago with cannabidiol CBD so let’s try and play this video we knew that cannabis had been used for epilepsy in the past in the past there is for example of translation of Arab story of the 15th century and it says that one of the Arab leaders had epilepsy physician came over and gave him cannabis and it

cured him but he had to take it for his entire life so the field kind of told us tried an epilepsy we first tried it in animals and it worked so at this point we decided to go into humans trial took place in Sao Paulo they had about ten people that had epilepsy that could not be affected by the known drugs we started giving them high doses of cannabidiol 200 milligrams per day and you are producing the cannabidiol from ashish for almost 40 years we didn’t produce it we isolated it we separated it from hashish hashish contains about 4% 5% cannabidiol so it is really quite difficult to isolate to obtain large amounts but we did that we were happy to note that indeed they had no seizures while they were taking cannabidiol and it was published and nothing happened afterwards so far 34 years later this is the only publication of cannabidiol in humans against epilepsy so just a short list of what CBD can do and on what it can walk starting from Alzheimer inflammation diabetes and of course sleep or wakefulness and this is done in many this was proven in many researchers later on in 1988 a cannabinoid receptor specific cannabinoid receptor was found in the brain and another receptor was found in the immune system so the situation was that we have a specific receptor for THC and this is that a bit it brings a question because receptors in our body are made for compounds that we produce not because there is a plant out there that produces compound so meshulam continuous research to find endogenous cannabinoids cannabinoids that we produce in my lab there were three collaborators who contributed a lot in this research my name zactly is linear Andre LaRouche when for socialism Czechoslovakia professor meshulam invited me i’m here already for 23 years but i can just for money earned it’s a little bit extended one year it was not enough for research he already had here postdoc peel devein dr. Devane in the states i go by bill in ireland i go by will he used to come late in the afternoon and work throughout the night and aviva broil she worked with me in the lab for about 30 years she still works with me in the lab she used to come early in the morning so sometimes they would meet here if it was five o’clock in the morning she would come in and he was just about to leave in three and a half years we never had a lab meeting looking for the endogenous cannabinoid a lot of brains were involved not only brains of the researchers well we initially worked and brains of pigs it is generally accepted that the organs of pigs and the ovens humans are somewhat closely related and probably pigs and humans are also some how closely related well I’m not sure that the pigs will be very happy to be related to humans but that’s something else so we wanted to work in pig brains and the pig brains are not so easy to get in Jerusalem it’s not kosher I took my car bill and I went to Tel Aviv bought a few kilos of big brain the butcher thought that we are having a party we are going to do something with it cook the brain each time that we came to buy it again so price was higher at the end it was very expensive I got the brain and just made some fractions and put it over a silica sand column and separate a few fractions and tested them for how they bound to the receptor and I thought oh it won’t take long you know I can just for one era but after one year baby miss bill still we didn’t have your compound so we asked professor meshulam

to extend Shalom a few other labs were already looking for compounds he thought we might be scooped by some other lab but we don’t you just try it with us we are very close and after about two years we found in extremely low amount it was only like a few droplets in the end of a little test tube a compound in the brain which acts on these receptors and of course as with every important discovery no single lab usually has all the expertise so Rafi was such a well-known figure in the field that he was able to put together a team of outstanding colleagues including Roger Pertwee I’m professor of neuropharmacology at the University of Aberdeen considered one of the top experts in cannabinoid receptor research that they then need to see whether it behaved like we expect a cannabinoid to behave so we just developed in USA doing that so they sent me some random ID and we were able to show in our laboratory that it did behave like we would expect to cannabinoid receptor Agnes to behave we’ve had other collaborations since then that was the most very much the most exciting one we hadn’t figured out the name of it yet oh the chemical name is al raha dont know ill ethanolamine we could have left its attack we thought that maybe it has to do with mood emotions things of that sort and therefore we thought well if it causes some kind of changes in emotion maybe it causes happiness we smoked marijuana it gives you a certain bliss so the natural compound also is responsible for that same type of the bliss and internal bliss that you have you know we looked for a good name and although some people do not agree with me but in Hebrew they are not too many names for happiness for sorrow you can find a lot of names but for happiness not for an extreme happiness we’ve looked into Assyrian things but the Syrian things are more complicated they called cannabis with van and a lot of THC they call it Gansey goo new well call of the compound Guns II guna was too complicated so we decided will go to something else I remember actually discussing the naming of this and I think it’s bill Devaney come out to the name right right Rafi sulem and Roger portray myself were all sitting outside in the Sun overlooking a nice little river and two years before I said to Rafi if I isolate this chemical I get to name it don’t I bill was interesting in the Sanskrit stories and he found that odd and ice bridge delight people who know me know that I study Eastern philosophy I know lots of sanskrit words you know Ananda means in Sanskrit supreme joy professor meshulam said you know it can be a good it will be a part just all chemical nature of this compound and because it’s a tunnel amide so we did ananda and a might say it’s Ananda might you they’ve made this discovery and published in this landmark paper and its importance is illustrated very well by the fact that it’s one of the very few papers in the biomedical literature that has been sighted over 2,000 times since its publication they even don’t cite it anymore because it’s considered such an well known thing an obvious thing that they don’t even cite our work anymore they mention Ananda Midas a and B and C it turned out that there is a whole system in the body which is involved around an and might and this in many respects parallels important systems that the body relies upon them and this system is called now the endocannabinoid system and a huge number of researchers are involved in investigating this system from many aspects I’m a full professor of biochemistry basis of my work was to understand how the nervous system works I usually go by dr. Mary a bit cb2 receptor instance we’re trying to discover how the world works or in our case how cannabinoids work and how the brain works are there additional

receptors at lino cb1 cb2 receptors and you see a difference between the oral administration versus the smoked form which is a very cool found which we haven’t managed to isolate yet but we strongly believe exists the endocannabinoid system is complex it’s very challenging even animal doing the inode patio is still pressing than ever is because he has loved a controlling it just perhaps not easy to describe actually how um continuing the ananda made the first endocannabinoid and it’s a very nice name I must say happiness or bliss called this compound and later on a second cannabinoid was found and Michelin when he was he was so certain about the safety of using cannabinoids of using THC that he went on trying dis compounds on children a scientist indeed as intellectuals we should try always to be skeptical so in 1995 we had an idea of testing THC on children it has been known for many years that cannabis can lower the effects of anti-cancer drugs anti-cancer drugs many of them cause terrible side effects and in children unfortunately children get canceled as well children vomit and want to vomit nausea they’re really in a bad shape and they cry all the time and their parents are in a bad shape luckily most of your children can be cured of the cancer but the treatment is absolutely the we wanted to do a clinical trial in children we did that with Professor avramov I abramo she was head of the department of pediatric oncology in one of the jerusalem hospitals and we did a major study with THC given in oily drops under the tongue of children obviously children cannot smoke we had children that were not even one year old we dropped she dropped THC in oil in olive oil under the tank at two or three times a day small doses during the anti-cancer treatment at the beginning we wanted to do a double-blind study some of the children got a THC some other children got only the olive oil after a week she told me i’m not going ahead with that I know exactly who is getting the THC I know exactly who is not getting it there was a complete separation those that didn’t get it continued to vomit so she went ahead doing an open study and she gave THC pure THC under the tank about 400 times which means that those that were involved in the experiment got it every time they were treated with whatever they were being treated and at the end we saw that we had complete complete block of vomiting complete block of nausea by small amount of THC we did not cause any psycho activity nothing so here we had a complete therapeutic effect and we publish that and again essentially nothing happened finito that was it it’s still not being used in children and you think it’s it’s a good idea to use it for but I believe it’s an excellent idea because we help those children that suffer but I have no influence on oncologists so actually it’s kind of repeating itself that his research is finding something amazing and then nothing happens I’m going to the next next next subject is cannabis for medicinal use in Israel but I will go quickly on that for me it started in 2007 although it was already approved in 1997 but it was kept as a secret as I told you it was the you two thousand when I wanted to help my mother I didn’t know there is an option to get a license

nobody knew during those first ten years only 10 people got a license and the Ministry of Health kept it as a secret in 2008 2007 a family decided to take upon themselves the growing and dispensing of cannabis for patients and they did it for free I joined as a volunteer and I got a special license to it’s in a blue so you have to believe me for the translation but the license was for rolling a dangerous drug ok this is the licensed at ahead and so I could officially roll a dangerous drug and that was the first license now if you have any problem with rolling a joint you can ask me later how to do it officially by the state of israel i can give you answers for that and we add we started with a small clinic in in one of the in a small house actually someone’s living room became small clinic where we could educate the patients so later on we I instructed more educators to help us when we started to grow little by little and sometimes patient needed help because they could not use the cannabis by themselves at that time we had only the options of rolling joints or maybe using a bong we didn’t have any edibles or any vaporizers in Israel so that was the only thing we did and as I mentioned a bonk but for all the people it was much easier to try this kind of water pipe it is not connected to smoking this is completely different for them and it was very helpful I will skip that clip because I think we don’t have much time but in the movie they were participating a lot of patients that agreed to open their story and i want to show just one of them David with who suffered from Parkinson’s disease and he was received the license for cannabis to alleviate the pain that is related to this disease but he found out that cannabis can do much more than that for him so let’s play the clip will contain a holy Pakistan if Nikki’s Melissa the Holy Pakistan of snow chill of the array dot similar what the KD Marla to bottom bony riccati mashallah any mold dr. dan yes no yeah was good questioning super Gekko

so actually that was a boo but you can see the difference in the handwriting shaky handwriting and then really clear and nice what happened after that scene was broadcast in the way in in the movie that neurologists decided to do a research about Parkinson’s and cannabis and they did this research in what they found out is this am a Eurasian of both motor and non-motor symptoms in patients with parkinson’s disease treated with cannabis very simple nothing happened afterwards don’t worry nobody’s doing anything with it so another result of the documentary was that one day I get a strange phone call hello my name is in Val and I’m the head nurse of huddle Nell single one of the patients got license for cannabis and I want you to come and help us we don’t know what to do with it oh kayy me she said I got your phone because you made the documentary you probably know something about canvas so I went to the caboose it was to this nursing home adam nelson go ms ass 36 skilled nursing facility with 36 patients and they all have difficulties with activities of daily living involved the nurse took me to see this patient she was total dementia sitting on the wheelchair groaning groaning not responding to anything not communicating arise running around and actually she was named by the nursing team not without affection the tiger and it I what we had is joints i wanted it was impossible to give this lady a joint she was not responding and growing a tiger so I asked the nurse if I can do something else and she said of course do whatever you want this lady was kicked out of any other nursing facilities and she’s here for the last three months and this is just terrible so do whatever you can so I actually took bonk they took a deep heat from that bong and just blew the smoke an inch from her mouth and it actually did the trick oops rapid response just a few minutes after she inhaled arise stopped running around she became quiet she even responded when we try when i call their name and then for the first time she isn’t she was admitted at the nursing home she smiled and even laughed and the nurse almost fainted and okay she told me okay you stay here you don’t go anywhere I have 36 patients and of course I couldn’t do the same trick again and again so a friend built a improvised smoke machine which was a kind of combination between a vaporizer and a bong and a TV report actually showed how it work Masha Allah Venetian Makhubela de cannabis leaf you even thought Michelle hum tambem you hi blitz a half before mcgivney and without Mahalo to parking zone whole hot vanaf Sekot at one point somebody decided that it is

worthwhile testing cannabis with relatively high doses of THC I believe in people that are Alzheimer alzheimer like patients they got it in their food in the yogurt of whatever some of them I believe not all of them but some of them were in a better shape some of them started speaking their eyes became brighter in one case in X writer started writing again in another case a woman said I feel fine and went home so it seems to be helping the symptoms of Alzheimer or senility alzheimer at the moment has a huge huge problem and there is very little that can be done for Alzheimer patients so maybe if it is well researched in the future we should know how to help these patients we are dealing here with population of millions and this population will grow because in most countries Western countries at least the number of all the people is growing all the time we are lucky that cannabis is not toxic people do not die from overdose of cannabis I did my degree in environmental school in Tel Aviv University and decreasing the use of medication is actually really really important to the environment because recently scientists all over the world are finding that residue of pharmaceutical that are coming mostly from human consumption in our water resources the the treating plant the treating the switch treating plant that’s supposed to filter the water is not designed to filter these molecules of pharmaceuticals so the pharma to the pharmaceuticals are getting to our water resources decreasing the use of medication with cannabis is also good for our environment in that sense this is the title of my research decreasing the consumption of conventional drugs together with significant health improvement through medical cannabis treatment and I’ll jump because we talked about a little bit and this is what cannabis was prescribed for different situation different ailments most of the patients will prescribe for pain then appetite spasticity agitation vulcan stones insomnia mood and ataxia and as you can see the there is more than 27 different situations here because some of the patient got it for more than one debilitating situation we use for different types of cannabis in a dream del singam a high TC strain without any CBD low THC strain without any CBD and then a kind of a balanced strain with twelve twelve percent CBD and THC and then a high CBD strain with very low THC and this was given to different ailments for different situations and of course we used smoking most of the patient finally used cannabis in ingesting actually with the porridge the easiest way of course just back to the first case because I want to show you the what happened with her weight loss she lost a few kilos before we started because she wasn’t eating actually because she was agitated and shouting and she didn’t want anyone to push her food but as we started you can see the halt in the reduction of the of the overweight and then the next year she starting to get gain some weight which is usually not the case for this

kind of situations and these are the medications that were discontinued throughout our treatment antipsychotics and zeolite exudative sedative and one for Alzheimer’s and the side effects of this kind of bit of all these medications is absolutely terrible actually the first one Cirque well as antipsychotic as an fda warning do not give it to dementia patients because it can kill them but it’s used everywhere all over the world in nursing home for dementia maybe that’s what they want to do with these patients but this is FDA red warning on the package of seroquel just another case that I will not results for the 27 patients health results it was of course pain relief improvement of appetite improve eating ability decreased in muscle construction contraction sorry improved sleep decreased use of sleeping pills of course and enema treatment that was routine part of this place like any other places was completely stopped just a quick example of spasticity this lady before the treatment totally [ __ ] the problem is not that she’s totally [ __ ] but think of how to treat her how to wash sometimes the the bones are broken because of this situation nothing helps but a few minutes after she inhaled cannabis this is the situation her hands are free look at the neck look at the situation of the head so the improvement for the patient symptom this table can be really confusing because as you see nine patients got cannabis for appetite but when we look at the files of the other patient I saw that 15 patients actually got better appetite and they didn’t get that cannabis for the appetite of course sleeping six patients slept better only one got it for sleeping this is what I call the positive side effects of cannabis now for PTSD of course no one got the license for PTSD but at that place we had two Holocaust survivors and both of them suffered from severe PTSD post-traumatic stress disorder and for the first time maybe in the life or at least since admitted at this place they stopped the dreams the nightmares the daytime anxiety they became relaxed again inflammation you c0 at the prescribed but to at the result so two of the patient that suffered from inflammation gout stopped there were no more inflammation and these are the 39 sorry 39 families of medication is anticonvulsants Alzheimer’s a dative antipsychotic out on the diabetic and zeolitic pay in Parkinson’s and laxatives sorry for saying it so fast but and these are the 25 different medications that were stopped and I thought that a better way to put it would would be actually like that much more visual so as I mentioned the influence and also on the environment is really important and if I have time now i will skip that and just just another case report because again it happened after the movie was screened and a family a father of a young boy called me and asked for my help and of course i helped and there it’s it yet a 11 year old boy suffered from autism of course agitation shouting scratching and wounding himself scratching and wounding everyone around him actually his father and mother are all wounded and they don’t tell at work what he told me that what he tells he said I was walking in the garden with the roses and got some because they didn’t want to tell anyone and he was always scared no sleep at all

and the parents actually told me that they are living in a it’s a living nightmare and we managed to get their license children don’t get licenses for cannabis what ism never and we with the help of Professor meshulam we got the license and started treatment and we treated the young boy with THC oil its cannabis extract but mostly THC and we started with one drop three times a day for the first two days in order to see that is there are no bad reaction to the cannabis but there was no reaction at all and we went up to two drops three times a day it was five milligrams of THC and on the fifth day when we raise the amount to seven and a half milligrams three times a day we saw little reduction in symptoms the fourth week of treatment brought with him amazing things no agitation no shouting and crying his skin was clean because he didn’t want it stopped wounding himself and started communicating a little bit and smiling it started to be a different child and it started to sleep at night so his balance could sleep at night and the first three months were different titration and trying to learn the dosage and sometimes there were problem with the supplier not always we had the same oil to use but after three months of treatment the boy that was before that it was one here at home not going to any kind of school now he was not agitated no shouting and crying clean skin as we mentioned this kept on going on sleep the whole night he created eye contact not very common for autism it became more verbal but more than that he got back to school after three months of treatment before they didn’t go to school for a year special school of course so this is where I say thank you